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Innovation in Joint Injury Regeneration and Treatment Through Biomaterials
Osteoarthritis is a degenerative joint disease that leads to cartilage wear, causing pain, stiffness, and loss of mobility in patients.
It is common in people over 55 years of age and is one of the leading causes of long-term disability. Since the disease has no cure, its treatment focuses on relieving the patient’s symptoms.
The cartilage tissue is a strong hydrogel which mechanical resistance is reached by a well-defined organization at the nanoscale. In this structure a “brush-like” agreccan molecule links to hyaluronic acid, and this large macromolecular complex to fibers of proteins (e.g., collagen, elastin).
The current cartilage regenerative hydrogels are built by a disorganized linkage (crosslinking) of macromolecules that strongly diverges from the structure natural cartilage.
Our research develops biomaterials that mimic natural cartilage. Through innovative hydrogels designed for injection during microfracture surgeries, the project aims for long-lasting regeneration, surpassing current treatments that only provide temporary pain relief.
This breakthrough could revolutionize cartilage treatments, offering more effective solutions and improved quality of life for millions of people suffering from chronic pain and disability.
We propose the preparation of a hydrogel biomimetic Aggrecan-hyaluronic acid nanostructure. The precise recreation of the natural cartilage would result in the actual regeneration of cartilage (not leding to fibrocartilage) and hence to long time pain relief. For an easy translation of the therapy we propose the combination of the hydrogel with common procedures to treat cartilage defects such as microfracture.
Is a Ramón y Cajal researcher at the ORCHID group in the Center of research in Nanomaterials and Biomedicine and (CINBIO) at the University of Vigo, Spain. His research focuses in the chemical modification and characterization of biomaterials (e.g. polysaccharides) for their application in drug delivery and regenerative therapies.
Is an Associate Researcher at the Group of Cell Therapy and Tissue Engineering (TERCIT) of the Health Research Institute of the Balearic Islands (IdISBa) and an Associate Professor at the University of the Balearic Islands, Spain. His research focuses on advanced biomaterials and regenerative therapies for musculoskeletal tissues regeneration.
“Consolidation of researchers with Excellent Trajectories”
Lorem ipsum dolor sit amet consectetur. Dictum commodo magna aenean venenatis condimentum facilisis. Libero nibh eu diam laoreet id volutpat. Ac senectus mauris vel consectetur
Lorem ipsum dolor sit amet consectetur. Dictum commodo magna aenean venenatis condimentum facilisis. Libero nibh eu diam laoreet id volutpat. Ac senectus mauris vel consectetur
Lorem ipsum dolor sit amet consectetur. Dictum commodo magna aenean venenatis condimentum facilisis. Libero nibh eu diam laoreet id volutpat. Ac senectus mauris vel consectetur
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